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Barcelona Cryo Center

Chronic / Postoperative Knee Pain

Targeted Cryoneurolysis for Persistent Knee Pain After Injury or Surgery

What Is It?

Persistent knee pain following surgery, trauma, or arthritis can result from overactive or damaged sensory nerves within the knee joint. Even after a successful knee replacement or arthroscopic procedure, many patients report lingering pain that limits their mobility, activity level, and quality of life.

In many cases, this pain is not caused by joint instability or mechanical failure — but rather by irritation or entrapment of the genicular nerves, which transmit pain from the knee to the brain.

Common symptoms include:

  • Persistent knee pain long after recovery from surgery or injury
  • Aching or burning pain with standing, walking, or climbing stairs
  • Tenderness around the front, side, or back of the knee
  • Increased sensitivity to pressure or temperature
  • Limited mobility due to pain, even with good joint healing

Common Causes

Cryoneurolysis may benefit knee pain resulting from:

  • Total knee replacement (TKR) or revision procedures
  • Post-arthroscopy or ligament repair surgery
  • Genicular nerve irritation or entrapment
  • Chronic inflammation or arthritis-related nerve sensitization
  • Residual pain with no clear structural cause

How Cryoneurolysis Helps

Barcelona Cryo Center performs ultrasound-guided cryoneurolysis to treat the genicular nerves — the primary sensory nerves responsible for knee pain. By applying precisely controlled cold therapy, these nerves are temporarily deactivated, stopping abnormal pain signals while preserving strength and joint function.

This approach is especially valuable for patients who have already tried medications, injections, or even surgery without sustained relief. Cryoneurolysis can also be performed while patients are waiting for surgery, providing meaningful pain relief and improved quality of life during the preoperative period.

Key Benefits:

  • Minimally invasive: No incisions or general anesthesia
  • Outpatient procedure: Done in the clinic with minimal downtime
  • Safe and repeatable: Relief may last several months per treatment
  • Joint-preserving: Targets nerves without affecting joint mechanics
  • Drug-free option: Reduces reliance on opioids or NSAIDs

Ideal Candidates

You may be a candidate for cryoneurolysis if you:

  • Have ongoing pain after knee surgery or injury
  • Experience sharp, aching, or burning pain around the knee
  • Have exhausted other conservative treatments
  • Want a nonsurgical, precision-based approach to relief

Step Toward Comfort and Mobility

Chronic knee pain can keep you from walking, working, and living the life you want. Cryoneurolysis offers a safe, targeted solution — helping you move with greater ease and less pain.

Book your consultation with Barcelona Cryo Center today.

Request a Consultation

Lower Extremity Conditions We Treat

We use cryoneurolysis to help patients manage a range of nerve-related pain conditions in the lower limbs:

  • Meralgia Paresthetica

    Burning, tingling, or numbness in the outer thigh due to compression of the lateral femoral cutaneous nerve.

    Learn More
  • Chronic / Postoperative Hip Pain

    Ongoing hip pain following surgery or due to arthritis, often involving the lateral femoral cutaneous or superior gluteal nerves.

    Learn More
  • Chronic / Postoperative Knee Pain

    Pain after knee replacement or injury, commonly linked to genicular nerve irritation.

    Learn More
  • Chronic / Postoperative Foot Pain

    Pain following foot surgery, trauma, or related to plantar fasciitis or nerve entrapment.

    Learn More
  • Morton’s Neuroma

    Sharp or burning pain between the toes due to thickened nerve tissue in the forefoot.

    Learn More
  • Plantar Fasciitis (Heel Spur)

    Heel pain from inflammation or irritation of the plantar fascia, often involving adjacent sensory nerves.

    Learn More

Ready to Feel Relief?

Explore the individual conditions listed above or book a consultation today to discuss whether cryoneurolysis is right for you.

Request a Consultation

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Clinic information

Medical Tuset Barcelona

C/ Tuset 23-25, entresuelo
08006 Barcelona

Opening hours

Tuesday: 9:00 to 14:00
Other days and times: by appointment

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